The protein, or a fragment or sequence variant thereof, according to any one of claims 1 and 3 to 12, wherein the human cells are human immune cells, preferably PBMCs.ġ4. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 to 11, wherein the protein has a length of no more than 400 amino acids.ġ3. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 to 10, wherein the protein comprises at least two cysteine residues.ġ2. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 to 9, wherein the protein is a bacterial protein, preferably of the human gastrointestinal tract microbiota metasecretome.ġ1. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 to 8, wherein the protein is a protein of human non-pathogenic microbiota.ġ0. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 to 7, wherein the protein is a bacterial protein, archaea protein, protist protein, fungi protein, virus protein and/or phage protein.ĩ. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 and 4 to 6, wherein the microbiota is gastrointestinal tract microbiota selected from gut microbiota and oral cavity microbiota.Ĩ.
#TEXMACS TEMPLATE SKIN#
The protein, or a fragment or sequence variant thereof, according to any one of claims 1, 4 and 5, wherein the microbiota is selected from the group consisting of gastrointestinal tract microbiota, lung microbiota, saliva microbiota, seminal fluid microbiota, skin microbiota and vagina microbiota.ħ. The protein, or a fragment or sequence variant thereof, according to any one of claims 1 to 4, wherein the protein is a protein of the metasecretome of non-pathogenic microbiota.Ħ. The protein according to claim 2 or 3, wherein the protein is a microbiota protein or a fragment or sequence variant thereof.ĥ. The protein according to claim 2, wherein the protein is capable of inducing and/or enhancing IL-10 secretion from human cells.Ĥ. A protein comprising or consisting of an amino acid sequence sharing at least 80% sequence identity with any one of SEQ ID NOs 1 to 10.ģ.
An isolated protein of non-pathogenic microbiota, or a fragment or sequence variant thereof, which is capable of inducing and/or enhancing IL-10 secretion from human cells.Ģ.
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